SOUTH BEND -- Notre Dame football suffered two key injuries during its College Football Playoff first-round game against Indiana Friday.

Starting right guard Rocco Spindler and starting defensive tackle Rylie Mills both suffered injuries. Spindler played a handful of series before coming out, eventually being seen in street clothes for the second half. It was unclear what injury Spindler suffered.

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Sam Pendleton came into the game to replace Spindler. Pendleton started the first seven games of the season at left guard.

Mills injured his knee while recording a sack on the Irish's first defensive snap of the second half. He limped off the field with the help of some Notre Dame staffers.

A sixth-year player, Mills has played in 62 games for the Irish, the third most in program history. Gabriel Rubio and Armel Mukam are the listed backups for Mills on the depth chart.

This article originally appeared on South Bend Tribune: Two starters injured for Notre Dame football in CFP first round game